Technology Platform

Hybrid Organ's technology platform provides innovative solutions for high density, three-dimensional cell culture methods. Human tissues are characterized, consisting of different cell types embedded in a specific and highly organized three-dimensional extra-cellular matrix. Bloodstream derived fluid exchange enables oxygenation and avoids large substrate gradients. Growth factors/ mediators produced systemically/locally stimulate cells to react specifically according to their physiological tasks in the tissue unit. Maintenance of stem cells in the tissue and differentiation of mature cells for organ function is dependent on such conditions.

Hybrid Organ’s proprietary technologies serve as a basis for the construction of bioreactors with respective control systems, as well as research and application services.

* Bioreactor systems based on:
Capillary membrane technology
Flat membrane technology
Ceramic foam technology

* Product groups for application in the areas of:
Clinical therapy with cells (The Hybrid Organ Modular Extracorporeal Liver System, ‘MELS’)
Production of diagnostic/ therapeutic substances with primary cells
Basic research on cell biology and for the pharmaceutical industry

* Clinical services:
Cell isolation of primary cells for clinical therapy
Expansion of patient cells
Cell system stand-by for clinics
Bioreactor application for patient treatments
Competent user training sessions and intensive courses for medical staff
The technology platform allows inventive research approaches in the areas of molecular biology, cell biology, bioengineering, chemical engineering, clinical and experimental surgery, tissue engineering and hybrid organ replacement.